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Article

Clinical, molecular, physiologic, and therapeutic feature of patients with CHRNA4 and CHRNB2 deficiency: A systematic review.

Journal of neurochemistry - 1 Jan 2025

Jalaiei Abbas, Asadi Mohammad Reza, Daneshmandpour Yousef, Rezazadeh Maryam, Ghafouri-Fard Soudeh

Abstract excerpt

The α4β2 nAChRs are crucial ion channels that control neurotransmitter release and play a role in various physiologic and pathologic processes. CHRNA4 encodes the α4-nAChRs, while CHRNB2 encodes the β2-nAChRs. Recent studies have found different variants of α4β2-nAChRs in individuals with conditions such as AD, ADHD, ALS, PD, and brain abnormalities. We conducted a scoping review following a six-stage methodology...

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PMID: 39193833
DOI: 10.1111/jnc.16200

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