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Neuroticism is linked to cognitive decline and increased risk of Alzheimer’s disease through dysregulation of excitatory neurons

2026-06-29

Abstract excerpt

<h4>INTRODUCTION</h4> Neuroticism is an established risk factor for Alzheimer’s disease (AD), yet the molecular mechanisms linking this personality trait to neurodegeneration remain poorly understood. <h4>METHODS</h4> We leveraged single-nucleus RNA-sequencing data from longitudinal cohort studies of cognitive aging (n = 655) to investigate the mechanisms mediating the association between neuroticism and AD. <h4...

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Literature Corpus work
daf388fb-04ac-50eb-b5a8-e36a4ae054d2
DOI
10.64898/2026.06.27.735015
Open publication

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Neuroticism is linked to cognitive decline and increased risk of Alzheimer’s disease through dysregulation of excitatory neuronsDOI 10.64898/2026.06.27.735015
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