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In vitro reconstitution of heterochromatin compartments reveals the spontaneous formation of tunable liquid-liquid interfaces.

Nucleic acids research - 24 Feb 2026

Brennan Lucy D, Kim Hyeong-Ku, Colmenares Serafin, Ego Tatum, Ryu Je-Kyung, Karpen Gary

Abstract excerpt

Compartmentalization of the genome into heterochromatin and euchromatin is a highly conserved and essential process across eukaryotes. Constitutive heterochromatin (C-Het) packages the repetitive regions of the genome within a biomolecular condensate formed through the enrichment of histone modification H3K9me3 and recruitment of its cognate reader protein heterochromatin protein-1 (HP1a). Linking the function of...

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Chromobox Protein Homolog 5
Chromosomal Proteins, Non-Histone
Drosophila Proteins
Euchromatin
Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41805129
DOI: 10.1093/nar/gkag201
PMCID: PMC12972904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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