Article

Phosphoserine clusters as metal ion sensors for protein phase separation

2026-05-29

Abstract excerpt

Phosphorylation is a major regulator of biomolecular condensation, yet it remains unclear whether clustered phosphoserines can directly tune phase behavior via metal-ion coordination. Here, using solution NMR spectroscopy and human heterochromatin protein 1α (HP1α) as a model system, we show that stepwise phosphorylation of its N-terminal serine cluster generates a dynamic metal-responsive module that engages Mg²⁺...

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Literature Corpus work: 040de71c-a01d-5409-a996-d198ab5991c8
DOI: 10.64898/2026.05.26.728006

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