Article

Myc inhibition triggers GM-CSF-driven regression of pancreatic tumours

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> The complex aetiology of pancreatic ductal adenocarcinoma (PDAC), together with its desmoplastic and hypoxic microenvironment, hinders effective treatment and contributes to its rapid lethality 1 . Using a reversibly switchable genetic mouse model that closely recapitulates human PDAC phenotype progression, we previously showed that selective deactivation of oncogenic Myc in PDAC epithelial cel...

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Literature Corpus work: 9e4d7005-7211-5361-a4cc-fcfad93feb40
DOI: 10.64898/2026.02.24.707647

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