Article

Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in pancreatic cancer

2025-12-08

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains a challenging disease in need of improved treatments. Cyclic adenosine monophosphate response element binding protein 1 (CREB) is an emerging therapeutic target whose oncogenic effects in PDAC have been largely attributed to a key molecular interplay between oncogenic Kras G12D/+ ( Kras* ) and chronic inflammation driving irreversible acinar to ductal reprogrammin...

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Literature Corpus work: ff2287d1-998b-5c5b-89fb-fe312562fa68
DOI: 10.64898/2025.12.04.691935

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