Article

B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma

2024-10-02

Abstract excerpt

<h4>Background</h4> The role of B cells in anti-tumor immunity remains controversial, with studies suggesting the pro-tumor and anti-tumor activity. This controversy may be due to the heterogeneity in B cell populations, as the balance among the subtypes may impact tumor progression. The immunosuppressive regulatory B cells (Breg) release IL-10 but only represent a minor population. Additionally, tumor-specific a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbefdb9f-e7c6-5c58-a6f5-f5a5f63ee074
DOI: 10.1101/2024.09.30.615831

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanomaDOI 10.1101/2024.09.30.615831Read

B10 cells: Development, phenotype, and function in cancer.Semantic proximity Read

Revealing the role of regulatory b cells in cancer: development, function and treatment significanceSemantic proximity Read

B cells spatial organization defines their phenotype and function in cancer "Tell me with whom you consort, and I will tell you who you are" - Goethe.Semantic proximity Read

Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapySemantic proximity Read

High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancerSemantic proximity Read

High tumor mutational burden (TMB) identifies a microsatellite stable pancreatic cancer subset with prolonged survival and strong anti-tumor immunity.Semantic proximity Read

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinomaSemantic proximity Read

Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic CancerSemantic proximity Read

Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.Semantic proximity Read

The role of B-1 cells in cancer progression and anti-tumor immunitySemantic proximity Read

ARF6-AMAP1 pathway induces pancreatic cancer cells to express immunosuppressive chemokinesSemantic proximity Read