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Article

Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer

7 Mar 2013

Abstract excerpt

The initiation and progression of pancreatic ductal adenocarcinoma (PDAC) is governed by a series of genetic and epigenetic changes, but it is still unknown whether these alterations are required for the maintenance of primary and metastatic PDAC. We show here that the c-Myc oncogene is upregulated throughout the entire process of neoplastic progression in human PDAC and in genetically engineered mice that...

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PMID: 23467612
DOI: 10.1158/0008-5472.can-12-2067

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