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A macrophage-derived noncanonical WNT niche drives immune exclusion in pancreatic cancer

2026-02-09

Abstract excerpt

<h4>Background and Aims</h4> Pancreatic ductal adenocarcinoma (PDAC) is characterized by profound immune exclusion and resistance to immunotherapy. Although WNT signaling has been implicated in PDAC, its cellular source within the tumor microenvironment and its contribution to immune suppression remain poorly defined. This study investigated whether myeloid-derived WNT signaling promotes PDAC progression. <h4>Met...

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Literature Corpus work
874710b5-c3f6-534f-aee3-ec08acc5709e
DOI
10.64898/2026.02.05.704114
Open publication

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A macrophage-derived noncanonical WNT niche drives immune exclusion in pancreatic cancerDOI 10.64898/2026.02.05.704114
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