Article

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma

2026-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Durable therapeutic efficacy remains a major barrier to improving outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). An immunosuppressive tumor microenvironment (TME) is a hallmark of PDAC and has been demonstrated to be a dominant driver of therapeutic resistance. The aberrant glycan CA19-9 is prevalent in PDAC and drives tumor progression, but the paracrine mechanisms by which...

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Literature Corpus work: bb1f2211-1d48-5eba-ac41-dac3fa7ab796
DOI: 10.64898/2026.05.22.727290

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