Identification and characterization of ADAR1 mutations and changes in gene expression in human cancers.

Abstract excerpt

ADAR1 (Adenosine deaminase action on RNA1) is involved in post-transcriptional RNA editing. ADAR1 mutations have been identified in many cancers but its role in tumor formation is still not well understood. Here we used available cancer genomes deposited on CSOMIC and cBioPortal to identify and characterize mutations and changes in ADAR1 expression in cancer cells. We identify several high frequency substitutions...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adenosine Deaminase
• Share to AKT1 gene
• Share to Gene Expression Regulation, Neoplastic