Article

Biochemical Profiling and Structural Basis of ADAR1-Mediated RNA Editing

2025-01-02

Abstract excerpt

<h4>Summary</h4> ADAR1 is a pivotal regulator in RNA-induced immune responses by catalyzing the conversion of adenosine to inosine on double-stranded RNA. Mutations on ADAR1 are associated with human autoimmune disease, and targeting ADAR1 has been proposed for cancer immunotherapy. However, the molecular mechanisms governing ADAR1-mediated RNA editing remain enigmatic. Here, we provide detailed biochemical and s...

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Literature Corpus work: 6df7ad1e-e94b-5389-9ab2-adfb42695122
DOI: 10.1101/2025.01.02.631069

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