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Article

A systematic evaluation of the therapeutic potential of endogenous-ADAR editors in cancer prevention and treatment.

NAR cancer - 1 Jun 2025

Merdler-Rabinowicz Rona, Dadush Ariel, Patiyal Sumeet, Rajagopal Padma Sheila, Daya Gulzar N, Ben-Aroya Shay, Schäffer Alejandro A, Eisenberg Eli, Ruppin Eytan, Levanon Erez Y

Abstract excerpt

Adenosine deaminases acting on RNA (ADAR) enzymes constitute a natural cellular mechanism that induces A-to-I(G) editing, introducing genetic changes at the RNA level. Recently, interest in the endogenous-ADAR editor has emerged for correcting genetic mutations, consisting of a programmed oligonucleotide that attracts the native ADAR, thereby offering opportunities for medical therapy. Here, we systematically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40330550
DOI: 10.1093/narcan/zcaf016
PMCID: PMC12053386

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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