Article

An RNA editing/binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

2016-07-08

Abstract excerpt

Adenosine-to-inosine (A-to-I) editing, catalysed by Adenosine DeAminases acting on double-stranded RNA (dsRNA) (ADAR), occurs predominantly in the 3’ untranslated regions (3’UTRs). Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target genes undergoing extensive 3’UTR editing. Using METTL7A (Methyltransferase Like 7A), a novel tumor suppressor as an exemplary target gen...

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Literature Corpus work: 917b9de8-941c-5ec9-8bb6-753364cf7991
DOI: 10.1101/062778

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