Article
RNA Editing Dynamically Rewrites the Cancer Code.
Trends in cancer - 1 Dec 2015
Rayon-Estrada Violeta, Papavasiliou F Nina, Harjanto Dewi
Abstract excerpt
Global analyses of cancer transcriptomes demonstrate that ADAR (adenosine deaminase, RNA-specific)-mediated RNA editing dynamically contributes to genetic alterations in cancer, and directly correlates with progression and prognosis. RNA editing is abundant and frequently elevated in cancer, and affects functionally and clinically relevant sites in both coding and non-coding regions of the transcriptome....
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