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Article

ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications

1 Nov 2019

Abstract excerpt

Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep. Here, we review current important ADAR-mediated editing events, related carcinogenic mechanisms and...

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Identifiers

PMID: 31930087
DOI: 10.21037/atm.2019.11.06

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