Article

Identification of first-in-class small molecule potential inhibitor of GDF15

2025-12-14

Abstract excerpt

<h4>Background</h4> Growth Differentiation Factor 15 (GDF15), a mitokine implicated in stress response, has been associated with numerous diseases, particularly cancer cachexia. Many approaches, including monoclonal antibodies and peptide antagonists, have been implemented to inhibit GDF15 activity. It is currently unknown whether it is possible to inhibit GDF15 using small organic molecules (SOMs). <h4>Methods</...

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Literature Corpus work: 265fbb4b-4dd9-5bb3-afbb-6a5ba97fb316
DOI: 10.64898/2025.12.12.693902

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