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Article

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

26 Apr 2021

Abstract excerpt

GDF15 is a distant TGF-β family member that induces anorexia and weight loss. Due to its function, GDF15 has attracted attention as a potential therapeutic for the treatment of obesity and its associated metabolic diseases. However, the pharmacokinetic and physicochemical properties of GDF15 present several challenges for its development as a therapeutic, including a short half-life, high aggregation propensity,...

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PMID: 33903632
DOI: 10.1038/s41598-021-87959-5

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