Back to search

Article

Mitochondrial DNA copy number in neurodegenerative diseases: a global meta-analysis of 156 comparisons across 76 studies

2026-08-29

Abstract excerpt

Mitochondria are central hubs for cellular metabolism and mitochondrial dysfunction is a hallmark of many chronic diseases. Consequently, changes in mitochondrial DNA copy number (mtDNA-CN), the number of mtDNA genomes per cell or tissue sample, are associated with diseases ranging from cancer and obesity to psoriasis and all-cause mortality. MtDNA-CN especially holds promise as a biomarker for neurodegenerative d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9e2faba1-8773-5b8f-899d-724c55faae79
DOI
10.64898/2026.08.25.747144
Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mitochondrial DNA copy number in neurodegenerative diseases: a global meta-analysis of 156 comparisons across 76 studiesDOI 10.64898/2026.08.25.747144
The Role of Mitochondrial Copy Number in Neurodegenerative Diseases: Present Insights and Future DirectionsSemantic proximity
Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brainSemantic proximity
Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseasesSemantic proximity
Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative diseaseSemantic proximity
Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review.Semantic proximity
Mitochondrial DNA Copy Number as a Potential Biomarker for the Severity of Motor Symptoms and Prognosis in Parkinson's DiseaseSemantic proximity
The Role of Mitochondrial genome abundance in Alzheimer’s DiseaseSemantic proximity
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolitesSemantic proximity
GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 73 loci and highlights a potential causal role in dementiaSemantic proximity
Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive FunctionSemantic proximity
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.Semantic proximity
Association between mitochondrial DNA copy number and the risk of Parkinson's disease: a meta-analysis and Mendelian randomization study.Semantic proximity
Select a neighboring publication to make it the new centre.