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Mitochondrial DNA Copy Number as a Potential Biomarker for the Severity of Motor Symptoms and Prognosis in Parkinson's Disease

6 Jan 2025

Abstract excerpt

BACKGROUND: Mitochondrial function influences Parkinson's disease (PD) through the accumulation of pathogenic alpha-synuclein, oxidative stress, impaired autophagy, and neuroinflammation. The mitochondrial DNA copy number (mtDNA-CN), representing the number of mitochondrial DNA copies within a cell, serves as an easily assessable proxy for mitochondrial function. OBJECTIVE: This study aimed to assess the...

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Genetic Neurodegenerative Diseases
Mitochondrial Function and Pathology
Parkinson's Disease Mechanisms and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39760477
DOI: 10.1002/mds.30098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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