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Article

Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review.

EBioMedicine - 1 Feb 2022

Valiente-Pallejà Alba, Tortajada Juan, Bulduk Bengisu K, Vilella Elisabet, Garrabou Glòria, Muntané Gerard, Martorell Lourdes

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) encodes 37 genes necessary for synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA alterations are known to cause mitochondrial disease (MitD), a clinically heterogeneous group of disorders that often present with neuropsychiatric symptoms. Understanding the nature and frequency of mtDNA alterations in health and disease could be a cornerstone in...

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Identifiers

PMID: 35085849
DOI: 10.1016/j.ebiom.2022.103815
PMCID: PMC8790490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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