Article

The Role of Mitochondrial genome abundance in Alzheimer’s Disease

2022-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial dysfunction is an early and prominent feature of Alzheimer’s disease (AD), with impaired energy metabolism preceding the onset of clinical symptoms. Here we propose an update to the mitochondrial dysfunction hypothesis of AD based on recent results examining the role of mitochondrial genome abundance in AD. In a large post-mortem study, we show that lower brain mitochondrial genome...

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Literature Corpus work: 0e91f066-568a-54e8-9252-720dc4edd82c
DOI: 10.1101/2022.05.27.22275698

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