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GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 73 loci and highlights a potential causal role in dementia

2021-04-14

Abstract excerpt

Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial function. The specific biological processes underpinning its regulation, and whether those processes are causative for disease, is an area of active investigation. We developed a novel method for array-based mtDNA-CN estimation suitable for biobank-scale studies, called “AutoMitoC”. We app...

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Literature Corpus work: 83eeaf3d-60b4-5390-b39c-f6149cccb2e1
DOI: 10.1101/2021.04.08.21255031

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