Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function

16 Mar 2023

Abstract excerpt

BACKGROUND AND OBJECTIVES: Previous studies suggest that lower mitochondrial DNA (mtDNA) copy number (CN) is associated with neurodegenerative diseases. However, whether mtDNA CN in whole blood is related to endophenotypes of Alzheimer disease (AD) and AD-related dementia (AD/ADRD) needs further investigation. We assessed the association of mtDNA CN with cognitive function and MRI measures in community-based...

Source

Identifiers

PMID: 36927883
DOI: 10.1212/wnl.0000000000207157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive FunctionPMID 36927883Read ↗

Mitochondrial DNA copy number is associated with cognitive function, cognitive decline, and dementia: a longitudinal study in UK BiobankSemantic proximity Read ↗

Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolitesSemantic proximity Read ↗

Mitochondrial DNA copy number associated dementia risk by somatic mutations and frailty.Semantic proximity Read ↗

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brainSemantic proximity Read ↗

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.Semantic proximity Read ↗

Blood-Based mtDNA Quantification Indicates Population-Specific Differences Associated with Alzheimer’s Disease-Related RiskSemantic proximity Read ↗

Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseasesSemantic proximity Read ↗

GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 73 loci and highlights a potential causal role in dementiaSemantic proximity Read ↗

The Role of Mitochondrial genome abundance in Alzheimer’s DiseaseSemantic proximity Read ↗

Mitochondrial DNA abundance in blood is associated with Alzheimer’s disease- and dementia-riskSemantic proximity Read ↗

The Role of Mitochondrial Copy Number in Neurodegenerative Diseases: Present Insights and Future DirectionsSemantic proximity Read ↗

Blood mitochondrial heteroplasmic variants and cognitive performance in late midlife: REGARDS study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.