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Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

6 Nov 2021

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer's disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden have both been associated with neurodegenerative diseases and cognitive decline. This study aims to systematically identify which common brain pathologies in the aged human brain are associated...

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PMID: 34742335
DOI: 10.1186/s13024-021-00495-8

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