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Association between mitochondrial DNA copy number and the risk of Parkinson's disease: a meta-analysis and Mendelian randomization study.

BMC neurology - 29 Sept 2025

Zheng Haoyang, Zhang Duo, Gan Yong, Wu Yuyi, Xiang Wei

Abstract excerpt

BACKGROUND: Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by both motor and non-motor symptoms, with mitochondrial dysfunction being a key pathological feature. Alterations in mitochondrial DNA copy number (mtDNA-CN) have been implicated in PD, but the relationship remains controversial. This study aimed to investigate the association between mtDNA-CN and PD through a meta-analysis...

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DNA Copy Number Variations
DNA, Mitochondrial
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

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PMID: 41023650
DOI: 10.1186/s12883-025-04400-4
PMCID: PMC12482262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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