Article

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria

2024-12-16

Abstract excerpt

<h4>ABSTRACT</h4> The NLRP11 protein is only expressed in primates and participates in the activation of the canonical NLRP3 and non-canonical NLRP3 inflammasome activation after infection with gram-negative bacteria. Here, we generated a series of defined NLRP11 deletion mutants to further analyze the role of NLRP11 in NLRP3 inflammasome activation. Like the complete NLRP11 deletion mutant ( NLRP11 -/- ), the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e2c5498-91b2-511b-ae0b-3b90f516d3cb
DOI: 10.1101/2024.12.11.627830

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteriaDOI 10.1101/2024.12.11.627830Read

NLRP11 promotes non-canonical inflammasome activation in human macrophages by enhancing caspase-4 recognition of cytosolic lipopolysaccharideSemantic proximity Read

The Roles of Inflammasomes in Host Defense against Mycobacterium tuberculosisSemantic proximity Read

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogensSemantic proximity Read

NLRP3 Inflammasome and Host Protection against Bacterial InfectionSemantic proximity Read

NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patternsSemantic proximity Read

The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling.Semantic proximity Read

Inflammasome activation via intracellular NLRs triggered by bacterial infectionSemantic proximity Read

The NAIP/NLRC4 inflammasomes.Semantic proximity Read

Caspase‐11: The driving factor for noncanonical inflammasomesSemantic proximity Read

The inflammasome in pathogen recognition and inflammationSemantic proximity Read

Sensing pathogens and danger signals by the inflammasome.Semantic proximity Read

NLRP3 recruitment by NLRC4 during <i>Salmonella</i> infectionSemantic proximity Read