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Article

NLRP3 Inflammasome and Host Protection against Bacterial Infection

1 Jan 2013

Abstract excerpt

The inflammasome is a multi-protein complex that induces maturation of inflammatory cytokines interleukin (IL)-1β and IL-18 through activation of caspase-1. Several nucleotide binding oligomerization domain-like receptor family members, including NLRP3, recognize unique microbial and danger components and play a central role in inflammasome activation. The NLRP3 inflammasome is critical for maintenance of...

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Identifiers

PMID: 24133343
DOI: 10.3346/jkms.2013.28.10.1415

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