Article

NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns

2024-02-08

Abstract excerpt

Inflammasomes are sensors that detect cytosolic microbial molecules or cellular damage, and in response they initiate a form of lytic regulated cell death called pyroptosis. Inflammasomes signal via homotypic protein-protein interactions where CARD or PYD domains are crucial for recruiting downstream partners. Here, we screened these domains from NLR family proteins, and found that the PYD domain of NLRP6 and NLRP...

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Identifiers and source

Literature Corpus work: 480439ab-0559-5843-bdf1-4586354f696a
DOI: 10.1101/2024.02.05.579000

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