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Article

Caspase‐11: The driving factor for noncanonical inflammasomes

1 Sept 2013

Abstract excerpt

Inflammasomes are large multiprotein platforms that mediate the processing of caspase-1, which in turn promotes the maturation and release of IL-1β and IL-18 in response to microbial and danger signals. While the canonical pathway of inflammasome activation has been known for some time, a novel mechanism of noncanonical inflammasome activation mediated by caspase-11 was more recently identified. This pathway...

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PMID: 24037676
DOI: 10.1002/eji.201343800

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