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Article

The inflammasome in pathogen recognition and inflammation

30 Apr 2007

Abstract excerpt

The nucleotide-binding oligomerization domain-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Some NLR family members promote the activation of proinflammatory caspases within multiprotein complexes, called inflammasomes. Recent studies analyzing mice deficient in various components of the inflammasome have provided insight into the role of...

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PMID: 17470531
DOI: 10.1189/jlb.1206755

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