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Article

NLRP3 recruitment by NLRC4 during <i>Salmonella</i> infection

2 May 2016

Abstract excerpt

NLRC4 and NLRP3, of the NOD-like receptor (NLR) family of intracellular proteins, are expressed in innate immune cells and are thought to nucleate distinct inflammasome complexes that promote caspase-1 activation, secretion of the proinflammatory cytokines IL-1β and IL-18, and a form of cell death termed pyroptosis. We show that NLRP3 associates with NLRC4 in macrophages infected with Salmonella typhimurium or...

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PMID: 27139490
DOI: 10.1084/jem.20132234

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