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Article

Inflammasome activation via intracellular NLRs triggered by bacterial infection

13 Oct 2011

Abstract excerpt

Members of the nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins assemble into a multiprotein platform, known as the inflammasome, to induce caspase-1 activation followed by the subsequent secretion of IL-1β and IL-18. In this review, we focus on the role of NLRs in inflammasome activation as part of the host defence against bacterial pathogens. One of activators of the NLRC4...

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Identifiers

PMID: 21995284
DOI: 10.1111/j.1462-5822.2011.01707.x

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