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Article

TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons

2 Oct 2022

Abstract excerpt

The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide-expressing (AGRP-expressing) neurons play an essential role in driving feeding, while also modulating nonfeeding behaviors. Besides AGRP, these neurons produce neuropeptide Y (NPY) and the neurotransmitter GABA, which act in concert to stimulate food intake...

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PMID: 36189793
DOI: 10.1172/jci162365

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