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Article

Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.

Results and problems in cell differentiation - 1 Jan 2010

Scherneck Stephan, Vogel Heike, Nestler Matthias, Kluge Reinhart, Schürmann Annette, Joost Hans-Georg

Abstract excerpt

Type 2 diabetes is a polygenic disease resulting from a combination of different disease alleles reflecting obesity, insulin resistance, and hyperglycemia. Using a positional cloning strategy with different inbred strains of mice, we mapped a disease locus for obesity-associated diabetes on chromosome 4. We analyzed all genes in this region and identified distinct differences in the expression levels of the...

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PMID: 20865372
DOI: 10.1007/978-3-642-14426-4_6

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