Article

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

2023-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Low antigen sensitivity and a gradual loss of effector functions limit the clinical applicability of chimeric antigen receptor (CAR)-modified T-cells and call for alternative antigen receptor designs for effective T-cell-based cancer immunotherapy. Here we applied advanced microscopy to demonstrate that TCR/CD3-based synthetic constructs (TCC) outperform second-generation CAR formats with regard...

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Literature Corpus work: 9dfd846d-c3d4-5014-b68e-e988da87d5c7
DOI: 10.1101/2023.03.16.532775

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