Back to search

Article

De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries

2024-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptors (CAR) that mimic T cell receptors (TCR) on eliciting peptide-major histocompatibility complex (pMHC) specific T cell responses hold great promise in the development of immunotherapies against solid tumors, infections, and autoimmune diseases. However, broad applications of TCR-mimic (TCRm) CARs are hindered to date largely due to lack of a facile approach for the effec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4a80ba00-0c81-572d-8dcf-1b9bb699f96d
DOI
10.1101/2024.11.27.625413
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell librariesDOI 10.1101/2024.11.27.625413
Significant Advancements and Evolutions in Chimeric Antigen Receptor DesignSemantic proximity
Chimeric Antigen Receptor (CAR) T Cells: A Detailed Review of Origins, Engineering, and Therapeutic ImpactSemantic proximity
Pooled screening of CAR T cells identifies non-native signaling domains for next-generation immunotherapiesSemantic proximity
The Anticancer Potential of T Cell Receptor-Engineered T Cells.Semantic proximity
Chimeric Antigen Receptors: A Paradigm Shift in ImmunotherapySemantic proximity
Synthetic Hybrid Receptors for Safer and Programmable T Cell TherapySemantic proximity
Building Better Chimeric Antigen Receptors for Adoptive T Cell TherapySemantic proximity
T Cell Activation Machinery: Form and Function in Natural and Engineered Immune ReceptorsSemantic proximity
Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapySemantic proximity
Engineering and Design of Chimeric Antigen ReceptorsSemantic proximity
CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptorsSemantic proximity
The rules of T-cell engagement: current state of CAR T cells and bispecific antibodies in B-cell lymphomasSemantic proximity
Select a neighboring publication to make it the new centre.