Chimeric antigen receptor signaling: Functional consequences and design implications

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has transformed the care of refractory B cell malignancies and holds tremendous promise for many aggressive tumors. Despite overwhelming scientific, clinical, and public interest in this rapidly expanding field, fundamental inquiries into CAR T cell mechanistic functioning are still in their infancy. Because CAR T cells are manufactured from donor T lymphocytes, and...

Topics

Join the communities discussing this publication.

• CAR-T cell therapy research
• Nanowire Synthesis and Applications
• Viral Infectious Diseases and Gene Expression in Insects