Article

High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells

2024-04-01

Abstract excerpt

<h4>SUMMARY</h4> Regulatory T cells (Tregs) are promising cellular therapies to induce immune tolerance in organ transplantation and autoimmune disease. The success of chimeric antigen receptor (CAR) T-cell therapy for cancer has sparked interest in using CARs to generate antigen-specific Tregs. Here, we compared CAR with endogenous T cell receptor (TCR)/CD28 activation in human Tregs. Strikingly, CAR Tregs displ...

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Identifiers and source

Literature Corpus work: 6fb56c33-6e38-58b8-916d-483866155b32
DOI: 10.1101/2024.03.31.587467

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