Article

CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites

2023-07-19

Abstract excerpt

Chimeric antigen receptors (CARs) are synthetic immune receptors that are expressed in T cells through genetic engineering. CAR-T cells have been successfully used to eradicate very advanced leukemias and lymphomas and their functional properties have been intensively studied. However, relatively little is known about the spatiotemporal expression and organization of CARs on the T-cell membrane and how this influe...

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Identifiers and source

Literature Corpus work: 4871f930-4529-5b44-bcdb-ddb5fed62a6a
DOI: 10.1101/2023.07.19.549702

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