Article

Unexpectedly High Subclonal Mutational Diversity in Human Colorectal Cancer and Its Significance

2019-06-21

Abstract excerpt

Human colorectal cancers (CRC) contain both clonal and subclonal mutations. Clonal mutations are positively selected, present in most cells and drive malignant progression. Subclonal mutations are randomly dispersed throughout the genome; they provide a vast reservoir of mutant cells that can expand, repopulate the tumor and result in the rapid emergence of resistance, as well as being a major contributor to tumor...

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Literature Corpus work: 790239d3-54fd-508c-8aad-9b81c6c426b6
DOI: 10.1101/672493

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