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Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA

2024-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Drug resistance is the major cause of therapeutic failure in high-grade serous ovarian cancer (HGSOC). Yet, the mechanisms by which tumors evolve to drug resistant states remains largely unknown. To address this, we aimed to exploit clone-specific genomic structural variations by combining scaled single-cell whole genome sequencing with longitudinally collected cell-free DNA (cfDNA), enabling cl...

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Literature Corpus work
680389db-5824-5321-8c21-8253c26a25ac
DOI
10.1101/2024.08.21.609031
Open publication

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Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNADOI 10.1101/2024.08.21.609031
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