Article

Early microglial activation in the TME enables FLASH-RT to eradicate medulloblastoma while promoting neuron-astrocyte crosstalk to minimize toxicity in the hippocampus

2026-03-18

Abstract excerpt

<h4>Background</h4> FLASH-RT defines a promising treatment modality against medulloblastoma, as it minimizes treatment-related complications. To support its clinical translation, we dissected the cellular and molecular determinants of the FLASH response in the tumor-microenvironment (TME) and healthy hippocampus using an orthotopic human medulloblastoma mouse model treated with a hypo-fractionated FLASH regimen....

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Identifiers and source

Literature Corpus work: 9de95ec6-7251-54b4-b730-779f2122d90a
DOI: 10.64898/2026.03.16.712103

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