Article

The inflammatory micro-environment induced by targeted CNS radiotherapy is underpinned by disruption of DNA methylation

2024-03-05

Abstract excerpt

Although targeted radiotherapy (RT) is integral to the increasing survival of cancer patients, it has significant side-effects, the cellular and molecular mechanisms of which are not fully understood. During RT epigenetic changes occur in neoplastic tissue, but few studies have assessed these in non-neoplastic tissue and results are highly variable. Using bulk DNA methylation and RNA sequencing as well as spatial...

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Literature Corpus work: b20b10a6-0aa6-5d33-acba-65c401703a50
DOI: 10.1101/2024.03.04.581366

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