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Article

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift

24 Mar 2014

Abstract excerpt

Glioblastoma is the most common adult primary brain tumor and has a dismal median survival. Radiation is a mainstay of treatment and significantly improves survival, yet recurrence is nearly inevitable. Better understanding the radiation response of glioblastoma will help improve strategies to treat this devastating disease. Here, we present a comprehensive study of the in vivo radiation response of glioma cells...

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Share to Cancer, Stress, Anesthesia, and Immune Response
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PMID: 24706837
DOI: 10.1073/pnas.1321014111

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