Article
Human pannexin mutations and their implications in erosive osteoarthritis.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2026
Tang Justin, Lu Jason, Johnston Danielle, Hoshijima Kazuyuki, Wakefield Brent, Bai Donglin, Stathopulos Peter B, Thompson Roger J, Lohman Alexander W, Jurynec Michael J, Beier Frank, Penuela Silvia
Abstract excerpt
Erosive hand osteoarthritis (EHOA) is a chronic joint disease characterized by severe inflammation and degeneration of cartilage and bone tissue. As this disease is multifactorial in nature, the molecular mechanisms that influence its pathogenesis are unclear, leading to a lack of disease-modifying therapies. However, by screening 40 families with a dominant inheritance pattern for EHOA, we identified two...
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