Article

Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical

2018-11-22

Abstract excerpt

Neurovascular coupling is the process by which neural activity causes localised changes in cerebral blood flow. Impaired neurovascular coupling has been suggested as an early pathogenic factor in Alzheimer’s disease (AD), and if so, could serve as an early biomarker of cerebral pathology. We have established an anaesthetic regime in which evoked hemodynamic responses are comparable to those in awake mice. This pro...

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Literature Corpus work: 9dde3ef3-ac0f-5b15-a497-c8b1a764599e
DOI: 10.1101/474916

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