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Article

Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variant.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jul 2011

Hahn Tim, Heinzel Sebastian, Plichta Michael M, Reif Andreas, Lesch Klaus-Peter, Fallgatter Andreas J

Abstract excerpt

Functional hyperemia, the brain's capability to alter microvascular blood flow in response to the metabolic demands of active neurons, is essential for sustained mammalian brain function. Pharmacological studies in mice suggest neurovascular coupling to centrally involve cyclooxygenase-1 (COX-1) metabolites such as prostaglandins. In humans, however, genetic variation of the COX-1 gene impacting the coupling of...

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PMID: 21097517
DOI: 10.1093/cercor/bhq236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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