Article

APOE4 and sedentary lifestyle synergistically impair neurovascular function in the visual cortex of awake mice

2024-07-02

Abstract excerpt

<title>Abstract</title> <p>Reduced cerebral blood flow occurs early in the development of Alzheimer’s disease (AD), suggesting an impairment in how the brain maintains its energy supply may contribute to disease onset. The ε4 allele of the Apolipoprotein (APOE) gene, the strongest risk factor for late onset AD, alters cerebrovascular function, increasing blood-brain barrier permeability. However, reports are mixe...

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Literature Corpus work: 04734052-34b7-5543-af29-36a446a7a39e
DOI: 10.21203/rs.3.rs-4486562/v1

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