Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling.

Experimental neurology - 1 May 2017

Lourenço Cátia F, Ledo Ana, Barbosa Rui M, Laranjinha João

Abstract excerpt

Nitric oxide (NO)-dependent pathways and cerebrovascular dysfunction have been shown to contribute to the cognitive decline and neurodegeneration observed in Alzheimer's disease (AD) but whether they represent initial factors or later changes of the disease is still a matter of debate. In this work, we aimed at investigating whether and to what extent neuronal-derived NO signaling and related neurovascular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Cerebrovascular Circulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Excitatory Amino Acid Agonists

Share to Glutamic Acid

Share to Maze Learning

Share to Nitric Oxide

Share to Nitric Oxide Synthase Type I

Share to Presenilin-1

Source

Identifiers

PMID: 28161255
DOI: 10.1016/j.expneurol.2017.01.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling.PMID 28161255Read ↗

Cerebrovascular phenotypes in mouse models of Alzheimer's disease.Semantic proximity Read ↗

Age-related impairment of cerebral blood flow response to KATP channel opener in Alzheimer's disease mice with presenilin-1 mutation.Semantic proximity Read ↗

Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimer's disease.Semantic proximity Read ↗

Amyloid and Tau Pathology are Associated with Cerebral Blood Flow in a Mixed Sample of Nondemented Older Adults with and without Vascular Risk Factors for Alzheimer’s DiseaseSemantic proximity Read ↗

Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is criticalSemantic proximity Read ↗

Cerebral blood flow in elastin haploinsufficient and 3xTg-AD miceSemantic proximity Read ↗

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model.Semantic proximity Read ↗

Critical threshold cerebral hypoperfusion causes Alzheimer's disease?Semantic proximity Read ↗

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology.Semantic proximity Read ↗

Linking cross-species trajectories of cerebrovascular remodeling in aging and Alzheimer’s disease to brain vessel transcriptomeSemantic proximity Read ↗

Neuronal and physiological correlation to hemodynamic resting-state fluctuations in health and disease.Semantic proximity Read ↗

Type 2 diabetes aggravates Alzheimer's disease-associated vascular alterations of the aorta in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.